| 1 | 1 | 2022-04-30 | regular_season | Angel City | 2–1 | Courage | BMO Stadium | 22000 |
| 2 | 1 | 2022-04-30 | regular_season | Thorns | 3–0 | KC Current | Providence Park | 13672 |
| 3 | 1 | 2022-05-01 | regular_season | Chicago Stars | 2–1 | Racing Lou | SeatGeek Stadium | 3028 |
| 4 | 1 | 2022-05-01 | regular_season | Spirit | 2–1 | Reign | Audi Field | 10177 |
| 5 | 1 | 2022-05-01 | regular_season | Dash | 0–1 | San Diego Wave | Shell Energy Stadium | 7722 |
| 6 | 1 | 2022-05-01 | regular_season | Pride | 0–3 | Gotham FC | Inter&Co Stadium | 4304 |
| 7 | 2 | 2022-05-08 | regular_season | San Diego Wave | 4–0 | Gotham FC | Torero Stadium | |
| 8 | 2 | 2022-05-08 | regular_season | KC Current | 0–2 | Dash | Children's Mercy Park | 6140 |
| 9 | 2 | 2022-05-08 | regular_season | Reign | 2–2 | Racing Lou | Lumen Field | 4396 |
| 10 | 2 | 2022-05-09 | regular_season | Angel City | 0–1 | Pride | BMO Stadium | |
| 11 | 3 | 2022-05-14 | regular_season | Thorns | 0–0 | Reign | Providence Park | 14496 |
| 12 | 3 | 2022-05-14 | regular_season | Pride | 2–2 | KC Current | Inter&Co Stadium | 3511 |
| 13 | 3 | 2022-05-15 | regular_season | Racing Lou | 1–1 | Dash | Lynn Family Stadium | |
| 14 | 3 | 2022-05-15 | regular_season | San Diego Wave | 2–1 | Chicago Stars | Torero Stadium | 5000 |
| 15 | 3 | 2022-05-15 | regular_season | Spirit | 0–1 | Angel City | Audi Field | 7433 |
| 16 | 4 | 2022-05-18 | regular_season | Courage | 1–2 | Pride | First Horizon Stadium at WakeMed Soccer Park | 3084 |
| 17 | 4 | 2022-05-18 | regular_season | Racing Lou | 1–0 | San Diego Wave | Lynn Family Stadium | 5302 |
| 18 | 4 | 2022-05-19 | regular_season | Thorns | 1–1 | Spirit | Providence Park | 9876 |
| 19 | 4 | 2022-05-21 | regular_season | Thorns | 0–2 | Dash | Providence Park | 14842 |
| 20 | 4 | 2022-05-22 | regular_season | Angel City | 1–0 | KC Current | BMO Stadium | 18514 |
| 21 | 4 | 2022-05-22 | regular_season | Courage | 0–1 | San Diego Wave | First Horizon Stadium at WakeMed Soccer Park | 6070 |
| 22 | 4 | 2022-05-22 | regular_season | Gotham FC | 0–1 | Racing Lou | Sports Illustrated Stadium | 2672 |
| 23 | 4 | 2022-05-22 | regular_season | Reign | 0–0 | Spirit | Lumen Field | 5846 |
| 24 | 4 | 2022-05-22 | regular_season | Pride | 2–4 | Chicago Stars | Inter&Co Stadium | 3015 |
| 25 | 5 | 2022-05-26 | regular_season | Reign | 1–0 | KC Current | Lumen Field | 3944 |
| 26 | 5 | 2022-05-27 | regular_season | Pride | 2–2 | Spirit | Inter&Co Stadium | 3586 |
| 27 | 5 | 2022-05-29 | regular_season | Chicago Stars | 2–2 | Thorns | SeatGeek Stadium | 3268 |
| 28 | 5 | 2022-05-29 | regular_season | Reign | 1–0 | San Diego Wave | Lumen Field | 5712 |
| 29 | 5 | 2022-05-29 | regular_season | Dash | 1–1 | Courage | Shell Energy Stadium | 4852 |
| 30 | 5 | 2022-05-30 | regular_season | Angel City | 0–1 | Gotham FC | BMO Stadium | 18784 |
| Rk | Wk | Date | Comp | Home | Score | Away | Venue | Attendance |
|---|
| 31 | 5 | 2022-05-30 | regular_season | KC Current | 1–0 | Racing Lou | Children's Mercy Park | 6484 |
| 32 | 6 | 2022-06-01 | regular_season | Spirit | 1–1 | Chicago Stars | Segra Field | 1961 |
| 33 | 6 | 2022-06-04 | regular_season | Dash | 5–0 | Pride | Shell Energy Stadium | 6073 |
| 34 | 6 | 2022-06-04 | regular_season | Thorns | 3–0 | Angel City | Providence Park | 14493 |
| 35 | 6 | 2022-06-04 | regular_season | Chicago Stars | 1–0 | Reign | SeatGeek Stadium | 3002 |
| 36 | 6 | 2022-06-04 | regular_season | Gotham FC | 1–0 | Spirit | Sports Illustrated Stadium | 6433 |
| 37 | 6 | 2022-06-05 | regular_season | KC Current | 2–2 | San Diego Wave | Children's Mercy Park | 7954 |
| 38 | 6 | 2022-06-05 | regular_season | Racing Lou | 0–3 | Courage | Lynn Family Stadium | 5738 |
| 39 | 8 | 2022-06-08 | regular_season | Angel City | 0–0 | Dash | BMO Stadium | 16739 |
| 40 | 2 | 2022-06-09 | regular_season | Chicago Stars | 0–0 | Spirit | SeatGeek Stadium | 2312 |
| 41 | 7 | 2022-06-09 | regular_season | San Diego Wave | 2–2 | Thorns | Torero Stadium | 6100 |
| 42 | 7 | 2022-06-11 | regular_season | Spirit | 2–3 | Courage | Segra Field | 4236 |
| 43 | 7 | 2022-06-12 | regular_season | KC Current | 1–0 | Gotham FC | Children's Mercy Park | 5695 |
| 44 | 7 | 2022-06-12 | regular_season | Racing Lou | 2–3 | Angel City | Lynn Family Stadium | 6139 |
| 45 | 7 | 2022-06-12 | regular_season | Chicago Stars | 1–0 | Pride | SeatGeek Stadium | 3881 |
| 46 | 7 | 2022-06-12 | regular_season | Dash | 0–4 | Thorns | Shell Energy Stadium | 5006 |
| 47 | 7 | 2022-06-12 | regular_season | San Diego Wave | 1–1 | Reign | Torero Stadium | 5000 |
| 48 | 8 | 2022-06-17 | regular_season | Spirit | 2–2 | Racing Lou | Segra Field | 2790 |
| 49 | 8 | 2022-06-19 | regular_season | KC Current | 2–2 | Chicago Stars | Children's Mercy Park | 6848 |
| 50 | 8 | 2022-06-19 | regular_season | Reign | 1–0 | Angel City | Lumen Field | 6367 |
| 51 | 8 | 2022-06-19 | regular_season | Thorns | 6–0 | Pride | Providence Park | 16185 |
| 52 | 8 | 2022-06-19 | regular_season | Gotham FC | 0–3 | San Diego Wave | Sports Illustrated Stadium | 7145 |
| 53 | 8 | 2022-06-19 | regular_season | Courage | 3–4 | Dash | First Horizon Stadium at WakeMed Soccer Park | 4117 |
| 54 | 9 | 2022-07-02 | regular_season | Reign | 2–0 | Courage | Lumen Field | 7519 |
| 55 | 9 | 2022-07-02 | regular_season | Angel City | 1–1 | Thorns | BMO Stadium | 17492 |
| 56 | 9 | 2022-07-02 | regular_season | Dash | 1–2 | KC Current | Shell Energy Stadium | 5007 |
| 57 | 9 | 2022-07-02 | regular_season | Gotham FC | 0–3 | Chicago Stars | Sports Illustrated Stadium | 3499 |
| 58 | 9 | 2022-07-03 | regular_season | San Diego Wave | 2–1 | Spirit | Torero Stadium | 6000 |
| 59 | 9 | 2022-07-04 | regular_season | Pride | 2–2 | Racing Lou | Daytona International Speedway Stadium | 7573 |
| 60 | 10 | 2022-07-08 | regular_season | Pride | 1–0 | Dash | Inter&Co Stadium | 3520 |
| Rk | Wk | Date | Comp | Home | Score | Away | Venue | Attendance |
|---|
| 61 | 10 | 2022-07-09 | regular_season | Racing Lou | 1–2 | Gotham FC | Lynn Family Stadium | 5771 |
| 62 | 10 | 2022-07-10 | regular_season | Angel City | 2–1 | San Diego Wave | BMO Stadium | 22000 |
| 63 | 10 | 2022-07-10 | regular_season | Spirit | 0–1 | KC Current | Segra Field | 2932 |
| 64 | 10 | 2022-07-10 | regular_season | Chicago Stars | 2–2 | Courage | SeatGeek Stadium | 4098 |
| 65 | 10 | 2022-07-10 | regular_season | Reign | 2–2 | Thorns | Lumen Field | 9032 |
| 66 | 11 | 2022-07-16 | regular_season | San Diego Wave | 0–0 | Racing Lou | Torero Stadium | 4747 |
| 67 | 11 | 2022-07-17 | regular_season | Dash | 4–1 | Chicago Stars | Shell Energy Stadium | 4637 |
| 68 | 11 | 2022-07-17 | regular_season | Thorns | 5–0 | Gotham FC | Providence Park | 16870 |
| 69 | 11 | 2022-07-17 | regular_season | Spirit | 0–0 | Pride | Audi Field | |
| 70 | 11 | 2022-07-17 | regular_season | KC Current | 1–0 | Reign | Children's Mercy Park | 7246 |
| 71 | 12 | 2022-07-29 | regular_season | Courage | 3–3 | Spirit | First Horizon Stadium at WakeMed Soccer Park | 5211 |
| 72 | 12 | 2022-07-30 | regular_season | Racing Lou | 1–2 | Thorns | Lynn Family Stadium | 7089 |
| 73 | 12 | 2022-07-31 | regular_season | Chicago Stars | 0–1 | San Diego Wave | Soldier Field | 23951 |
| 74 | 12 | 2022-07-31 | regular_season | Angel City | 2–3 | Reign | BMO Stadium | 22000 |
| 75 | 12 | 2022-07-31 | regular_season | Gotham FC | 2–4 | Dash | Sports Illustrated Stadium | 5631 |
| 76 | 12 | 2022-07-31 | regular_season | KC Current | 2–2 | Pride | Children's Mercy Park | 7192 |
| 77 | 13 | 2022-08-03 | regular_season | Racing Lou | 1–1 | Reign | Lynn Family Stadium | 5107 |
| 78 | 13 | 2022-08-06 | regular_season | Racing Lou | 1–1 | Spirit | Lynn Family Stadium | 5364 |
| 79 | 13 | 2022-08-06 | regular_season | Thorns | 3–3 | Courage | Providence Park | 17139 |
| 80 | 13 | 2022-08-07 | regular_season | San Diego Wave | 1–2 | KC Current | Torero Stadium | 4471 |
| 81 | 13 | 2022-08-07 | regular_season | Chicago Stars | 2–0 | Gotham FC | SeatGeek Stadium | 5078 |
| 82 | 13 | 2022-08-07 | regular_season | Reign | 1–2 | Dash | Lumen Field | 7252 |
| 83 | 13 | 2022-08-07 | regular_season | Pride | 2–2 | Angel City | Inter&Co Stadium | 4904 |
| 84 | 14 | 2022-08-11 | regular_season | Spirit | 1–2 | Thorns | Segra Field | 3037 |
| 85 | 14 | 2022-08-13 | regular_season | Dash | 0–0 | Racing Lou | Shell Energy Stadium | 5279 |
| 86 | 14 | 2022-08-14 | regular_season | San Diego Wave | 0–1 | Pride | Torero Stadium | 4418 |
| 87 | 14 | 2022-08-14 | regular_season | Courage | 3–4 | KC Current | First Horizon Stadium at WakeMed Soccer Park | 5092 |
| 88 | 14 | 2022-08-14 | regular_season | Reign | 4–1 | Gotham FC | Lumen Field | 7048 |
| 89 | 14 | 2022-08-15 | regular_season | Angel City | 1–0 | Chicago Stars | BMO Stadium | 17002 |
| 90 | 15 | 2022-08-18 | regular_season | Dash | 2–1 | Gotham FC | Shell Energy Stadium | 4753 |
| Rk | Wk | Date | Comp | Home | Score | Away | Venue | Attendance |
|---|
| 91 | 15 | 2022-08-20 | regular_season | KC Current | 1–1 | Angel City | Children's Mercy Park | 10395 |
| 92 | 15 | 2022-08-20 | regular_season | Gotham FC | 1–2 | Pride | Subaru Park | 4107 |
| 93 | 15 | 2022-08-20 | regular_season | Courage | 4–0 | Chicago Stars | First Horizon Stadium at WakeMed Soccer Park | 3571 |
| 94 | 15 | 2022-08-21 | regular_season | San Diego Wave | 3–1 | Dash | Torero Stadium | 5281 |
| 95 | 2 | 2022-08-24 | regular_season | Courage | 3–1 | Thorns | First Horizon Stadium at WakeMed Soccer Park | 3114 |
| 96 | 16 | 2022-08-26 | regular_season | Pride | 1–2 | Reign | Inter&Co Stadium | 4588 |
| 97 | 16 | 2022-08-27 | regular_season | Racing Lou | 0–4 | Chicago Stars | Lynn Family Stadium | 8729 |
| 98 | 16 | 2022-08-28 | regular_season | Dash | 2–2 | Spirit | Shell Energy Stadium | 5031 |
| 99 | 16 | 2022-08-28 | regular_season | Thorns | 0–2 | San Diego Wave | Providence Park | 18624 |
| 100 | 16 | 2022-08-28 | regular_season | Gotham FC | 1–3 | Angel City | Sports Illustrated Stadium | 6796 |
| 101 | 16 | 2022-08-28 | regular_season | KC Current | 3–2 | Courage | Children's Mercy Park | 7395 |
| 102 | 3 | 2022-09-04 | regular_season | Gotham FC | 0–1 | Courage | Sports Illustrated Stadium | 3124 |
| 103 | 17 | 2022-09-09 | regular_season | Pride | 0–2 | Thorns | Inter&Co Stadium | 3515 |
| 104 | 17 | 2022-09-10 | regular_season | Reign | 2–2 | Chicago Stars | Lumen Field | 7427 |
| 105 | 17 | 2022-09-10 | regular_season | Spirit | 4–3 | San Diego Wave | Audi Field | 10158 |
| 106 | 17 | 2022-09-10 | regular_season | Courage | 5–1 | Racing Lou | First Horizon Stadium at WakeMed Soccer Park | 3297 |
| 107 | 17 | 2022-09-11 | regular_season | Gotham FC | 0–1 | KC Current | Sports Illustrated Stadium | 2130 |
| 108 | 17 | 2022-09-11 | regular_season | Dash | 1–1 | Angel City | Shell Energy Stadium | 5927 |
| 109 | 11 | 2022-09-14 | regular_season | Courage | 1–0 | Angel City | First Horizon Stadium at WakeMed Soccer Park | 3661 |
| 110 | 18 | 2022-09-15 | regular_season | Chicago Stars | 4–0 | KC Current | SeatGeek Stadium | 2135 |
| 111 | 18 | 2022-09-16 | regular_season | Racing Lou | 2–0 | Pride | Lynn Family Stadium | 5397 |
| 112 | 18 | 2022-09-17 | regular_season | Spirit | 2–0 | Gotham FC | Audi Field | 8781 |
| 113 | 18 | 2022-09-17 | regular_season | Courage | 1–2 | Reign | First Horizon Stadium at WakeMed Soccer Park | 6398 |
| 114 | 18 | 2022-09-18 | regular_season | Chicago Stars | 0–1 | Dash | SeatGeek Stadium | 5488 |
| 115 | 18 | 2022-09-18 | regular_season | San Diego Wave | 1–0 | Angel City | Snapdragon Stadium | 32000 |
| 116 | 18 | 2022-09-18 | regular_season | KC Current | 1–1 | Thorns | Children's Mercy Park | 9281 |
| 117 | 19 | 2022-09-21 | regular_season | Gotham FC | 0–1 | Reign | Sports Illustrated Stadium | 2274 |
| 118 | 19 | 2022-09-21 | regular_season | Pride | 0–3 | Courage | Inter&Co Stadium | 3258 |
| 119 | 19 | 2022-09-22 | regular_season | Thorns | 3–0 | Racing Lou | Providence Park | 15652 |
| 120 | 19 | 2022-09-22 | regular_season | Angel City | 2–1 | Spirit | BMO Stadium | 16112 |
| Rk | Wk | Date | Comp | Home | Score | Away | Venue | Attendance |
|---|
| 121 | 19 | 2022-09-24 | regular_season | Courage | 3–0 | Gotham FC | First Horizon Stadium at WakeMed Soccer Park | 6376 |
| 122 | 19 | 2022-09-25 | regular_season | Dash | 0–2 | Reign | Shell Energy Stadium | 7798 |
| 123 | 19 | 2022-09-25 | regular_season | KC Current | 3–0 | Spirit | Children's Mercy Park | 9593 |
| 124 | 19 | 2022-09-25 | regular_season | Thorns | 3–0 | Chicago Stars | Providence Park | 19127 |
| 125 | 19 | 2022-09-25 | regular_season | Pride | 2–2 | San Diego Wave | Inter&Co Stadium | 6466 |
| 126 | 19 | 2022-09-26 | regular_season | Angel City | 1–3 | Racing Lou | BMO Stadium | 22000 |
| 127 | 20 | 2022-10-01 | regular_season | San Diego Wave | 0–0 | Courage | Snapdragon Stadium | 18000 |
| 128 | 20 | 2022-10-01 | regular_season | Gotham FC | 3–3 | Thorns | Sports Illustrated Stadium | 4752 |
| 129 | 20 | 2022-10-01 | regular_season | Spirit | 1–2 | Dash | Audi Field | 9141 |
| 130 | 20 | 2022-10-01 | regular_season | Racing Lou | 1–0 | KC Current | Lynn Family Stadium | 6622 |
| 131 | 20 | 2022-10-02 | regular_season | Reign | 3–0 | Pride | Lumen Field | 10746 |
| 132 | 20 | 2022-10-02 | regular_season | Chicago Stars | 2–0 | Angel City | SeatGeek Stadium | 8347 |