| 1 | | 2021-05-15 | regular_season | Racing Lou | 0–0 | KC Current | Lynn Family Stadium | 6622 |
| 2 | | 2021-05-15 | regular_season | Gotham FC | 1–0 | Dash | Sports Illustrated Stadium | |
| 3 | | 2021-05-16 | regular_season | Reign | 0–0 | Courage | Cheney Stadium | 2104 |
| 4 | | 2021-05-16 | regular_season | Pride | 1–1 | Spirit | Inter&Co Stadium | |
| 5 | | 2021-05-16 | regular_season | Thorns | 5–0 | Chicago Stars | Providence Park | |
| 6 | | 2021-05-21 | regular_season | Racing Lou | 2–0 | Spirit | Lynn Family Stadium | 6011 |
| 7 | | 2021-05-22 | regular_season | Courage | 1–2 | Pride | First Horizon Stadium at WakeMed Soccer Park | 5048 |
| 8 | | 2021-05-23 | regular_season | Chicago Stars | 0–0 | Gotham FC | SeatGeek Stadium | 3121 |
| 9 | | 2021-05-23 | regular_season | Thorns | 1–2 | Reign | Providence Park | |
| 10 | | 2021-05-23 | regular_season | Dash | 2–2 | KC Current | Shell Energy Stadium | 3034 |
| 11 | | 2021-05-26 | regular_season | Pride | 2–1 | Thorns | Inter&Co Stadium | 3407 |
| 12 | | 2021-05-27 | regular_season | Spirit | 2–1 | Dash | Shell Energy Stadium | 2241 |
| 13 | | 2021-05-27 | regular_season | KC Current | 0–2 | Chicago Stars | Legends Field | 5272 |
| 14 | | 2021-05-28 | regular_season | Courage | 5–0 | Racing Lou | First Horizon Stadium at WakeMed Soccer Park | 3902 |
| 15 | | 2021-05-29 | regular_season | Dash | 2–1 | Chicago Stars | Shell Energy Stadium | |
| 16 | | 2021-05-30 | regular_season | Gotham FC | 0–1 | Thorns | Sports Illustrated Stadium | 2750 |
| 17 | | 2021-05-30 | regular_season | Pride | 1–0 | KC Current | Inter&Co Stadium | 4044 |
| 18 | | 2021-05-30 | regular_season | Reign | 0–1 | Spirit | Cheney Stadium | 2537 |
| 19 | | 2021-06-05 | regular_season | Chicago Stars | 1–0 | Courage | SeatGeek Stadium | |
| 20 | | 2021-06-05 | regular_season | Gotham FC | 1–0 | Reign | Sports Illustrated Stadium | 2601 |
| 21 | | 2021-06-06 | regular_season | Thorns | 3–0 | Racing Lou | Providence Park | |
| 22 | | 2021-06-06 | regular_season | KC Current | 0–1 | Dash | Legends Field | 4265 |
| 23 | | 2021-06-06 | regular_season | Spirit | 1–1 | Pride | Audi Field | 5199 |
| 24 | | 2021-06-19 | regular_season | Courage | 2–1 | Reign | First Horizon Stadium at WakeMed Soccer Park | 5026 |
| 25 | | 2021-06-20 | regular_season | Chicago Stars | 1–1 | Spirit | SeatGeek Stadium | 3296 |
| 26 | | 2021-06-20 | regular_season | Racing Lou | 1–0 | Dash | Lynn Family Stadium | 5971 |
| 27 | | 2021-06-20 | regular_season | Thorns | 1–0 | KC Current | Providence Park | |
| 28 | | 2021-06-20 | regular_season | Pride | 1–1 | Gotham FC | Inter&Co Stadium | 4454 |
| 29 | | 2021-06-23 | regular_season | Reign | 2–0 | Chicago Stars | Cheney Stadium | 2518 |
| 30 | | 2021-06-23 | regular_season | KC Current | 1–3 | Pride | Legends Field | 4197 |
| Rk | Wk | Date | Comp | Home | Score | Away | Venue | Attendance |
|---|
| 31 | | 2021-06-23 | regular_season | Racing Lou | 0–2 | Courage | Lynn Family Stadium | 6334 |
| 32 | | 2021-06-26 | regular_season | Chicago Stars | 0–3 | Racing Lou | SeatGeek Stadium | 2626 |
| 33 | | 2021-06-26 | regular_season | Reign | 0–3 | Gotham FC | Cheney Stadium | 3007 |
| 34 | | 2021-06-26 | regular_season | Courage | 2–0 | Thorns | First Horizon Stadium at WakeMed Soccer Park | |
| 35 | | 2021-06-27 | regular_season | Dash | 2–1 | Pride | Shell Energy Stadium | 4693 |
| 36 | | 2021-06-27 | regular_season | KC Current | 1–2 | Spirit | Legends Field | 5157 |
| 37 | | 2021-07-02 | regular_season | Spirit | 0–1 | Chicago Stars | Segra Field | 3201 |
| 38 | | 2021-07-03 | regular_season | Gotham FC | 1–1 | KC Current | Sports Illustrated Stadium | 2307 |
| 39 | | 2021-07-03 | regular_season | Dash | 2–0 | Reign | Shell Energy Stadium | 4337 |
| 40 | | 2021-07-03 | regular_season | Racing Lou | 0–2 | Thorns | Lynn Family Stadium | 6822 |
| 41 | | 2021-07-04 | regular_season | Pride | 0–2 | Courage | Inter&Co Stadium | 3926 |
| 42 | | 2021-07-09 | regular_season | Pride | 1–1 | Racing Lou | Inter&Co Stadium | 3606 |
| 43 | | 2021-07-10 | regular_season | Spirit | 2–0 | Courage | Audi Field | 4929 |
| 44 | | 2021-07-11 | regular_season | Thorns | 0–0 | Gotham FC | Providence Park | 14731 |
| 45 | | 2021-07-11 | regular_season | Chicago Stars | 2–1 | Dash | SeatGeek Stadium | 2520 |
| 46 | | 2021-07-11 | regular_season | Reign | 2–0 | KC Current | Cheney Stadium | 3124 |
| 47 | | 2021-07-17 | regular_season | Courage | 1–2 | Dash | First Horizon Stadium at WakeMed Soccer Park | 5229 |
| 48 | | 2021-07-18 | regular_season | Spirit | 2–3 | Gotham FC | Segra Field | 2233 |
| 49 | | 2021-07-18 | regular_season | Chicago Stars | 3–1 | Reign | SeatGeek Stadium | 3301 |
| 50 | | 2021-07-19 | regular_season | Thorns | 2–1 | Pride | Providence Park | 14985 |
| 51 | | 2021-07-24 | regular_season | KC Current | 0–0 | Courage | Legends Field | 5239 |
| 52 | | 2021-07-24 | regular_season | Pride | 0–2 | Reign | Inter&Co Stadium | 4180 |
| 53 | | 2021-07-25 | regular_season | Dash | 0–1 | Thorns | Shell Energy Stadium | 1929 |
| 54 | | 2021-07-25 | regular_season | Racing Lou | 0–2 | Spirit | Lynn Family Stadium | 6422 |
| 55 | | 2021-07-25 | regular_season | Gotham FC | 2–1 | Chicago Stars | Sports Illustrated Stadium | 2487 |
| 56 | | 2021-07-31 | regular_season | Courage | 1–1 | Pride | First Horizon Stadium at WakeMed Soccer Park | 5523 |
| 57 | | 2021-08-01 | regular_season | Reign | 2–0 | Racing Lou | Cheney Stadium | 3097 |
| 58 | | 2021-08-01 | regular_season | Thorns | 2–0 | KC Current | Providence Park | 16246 |
| 59 | | 2021-08-01 | regular_season | Chicago Stars | 3–1 | Spirit | SeatGeek Stadium | 2534 |
| 60 | | 2021-08-01 | regular_season | Dash | 1–1 | Gotham FC | Shell Energy Stadium | 3517 |
| Rk | Wk | Date | Comp | Home | Score | Away | Venue | Attendance |
|---|
| 61 | | 2021-08-07 | regular_season | Gotham FC | 0–1 | Courage | Sports Illustrated Stadium | 2179 |
| 62 | | 2021-08-07 | regular_season | Spirit | 0–1 | Thorns | Segra Field | 2899 |
| 63 | | 2021-08-08 | regular_season | Reign | 5–1 | Dash | Cheney Stadium | 2922 |
| 64 | | 2021-08-08 | regular_season | Racing Lou | 3–1 | KC Current | Lynn Family Stadium | 5843 |
| 65 | | 2021-08-08 | regular_season | Chicago Stars | 0–2 | Pride | SeatGeek Stadium | 3298 |
| 66 | | 2021-08-14 | regular_season | Dash | 2–2 | Spirit | Shell Energy Stadium | 3167 |
| 67 | | 2021-08-14 | regular_season | Pride | 1–1 | Thorns | Inter&Co Stadium | 4209 |
| 68 | | 2021-08-15 | regular_season | KC Current | 1–0 | Reign | Legends Field | |
| 69 | | 2021-08-15 | regular_season | Gotham FC | 1–1 | Racing Lou | Sports Illustrated Stadium | 2200 |
| 70 | | 2021-08-15 | regular_season | Courage | 1–0 | Chicago Stars | First Horizon Stadium at WakeMed Soccer Park | 5002 |
| 71 | | 2021-08-19 | regular_season | Racing Lou | 1–1 | Chicago Stars | Lynn Family Stadium | 7310 |
| 72 | | 2021-08-21 | regular_season | Courage | 4–0 | KC Current | First Horizon Stadium at WakeMed Soccer Park | 4943 |
| 73 | | 2021-08-22 | regular_season | Reign | 3–2 | Gotham FC | Cheney Stadium | 3657 |
| 74 | | 2021-08-22 | regular_season | Spirit | 2–1 | Pride | Audi Field | 6002 |
| 75 | | 2021-08-26 | regular_season | Thorns | 2–1 | Gotham FC | Providence Park | 14299 |
| 76 | | 2021-08-26 | regular_season | KC Current | 2–1 | Racing Lou | Legends Field | 3997 |
| 77 | | 2021-08-29 | regular_season | Chicago Stars | 3–0 | KC Current | SeatGeek Stadium | 3536 |
| 78 | | 2021-08-29 | regular_season | Gotham FC | 0–1 | Pride | Sports Illustrated Stadium | 7035 |
| 79 | | 2021-08-29 | regular_season | Spirit | 0–0 | Courage | Audi Field | 4554 |
| 80 | | 2021-08-29 | regular_season | Dash | 1–0 | Racing Lou | Shell Energy Stadium | 3292 |
| 81 | | 2021-08-29 | regular_season | Reign | 2–1 | Thorns | Lumen Field | 27278 |
| 82 | | 2021-09-02 | regular_season | Dash | 0–1 | Reign | Shell Energy Stadium | |
| 83 | | 2021-09-04 | regular_season | Gotham FC | 0–0 | Chicago Stars | Sports Illustrated Stadium | 3252 |
| 84 | | 2021-09-04 | regular_season | Racing Lou | 1–1 | Reign | Lynn Family Stadium | |
| 85 | | 2021-09-05 | regular_season | Pride | 1–1 | Dash | Inter&Co Stadium | |
| 86 | | 2021-09-05 | regular_season | KC Current | 0–0 | Courage | Legends Field | 4583 |
| 87 | | 2021-09-11 | regular_season | Dash | 1–1 | Chicago Stars | Shell Energy Stadium | 3155 |
| 88 | | 2021-09-11 | regular_season | Pride | 3–1 | Racing Lou | Inter&Co Stadium | 3822 |
| 89 | | 2021-09-12 | regular_season | Courage | 0–1 | Thorns | First Horizon Stadium at WakeMed Soccer Park | 5161 |
| 90 | | 2021-09-25 | regular_season | Gotham FC | 3–1 | Courage | Sports Illustrated Stadium | 2887 |
| Rk | Wk | Date | Comp | Home | Score | Away | Venue | Attendance |
|---|
| 91 | | 2021-09-26 | regular_season | Chicago Stars | 2–1 | Thorns | SeatGeek Stadium | 3527 |
| 92 | | 2021-09-26 | regular_season | Racing Lou | 0–4 | Dash | Lynn Family Stadium | 6374 |
| 93 | | 2021-09-26 | regular_season | Spirit | 2–1 | KC Current | Segra Field | 3295 |
| 94 | | 2021-09-26 | regular_season | Reign | 3–0 | Pride | Cheney Stadium | 5044 |
| 95 | | 2021-10-06 | regular_season | Courage | 3–1 | Racing Lou | First Horizon Stadium at WakeMed Soccer Park | 3523 |
| 96 | | 2021-10-06 | regular_season | Gotham FC | 0–0 | Spirit | Subaru Park | 9532 |
| 97 | | 2021-10-07 | regular_season | Thorns | 2–3 | Dash | Providence Park | 11139 |
| 98 | | 2021-10-09 | regular_season | Pride | 2–3 | Gotham FC | Inter&Co Stadium | |
| 99 | | 2021-10-09 | regular_season | Spirit | 3–0 | Racing Lou | Audi Field | 4450 |
| 100 | | 2021-10-10 | regular_season | Dash | 4–1 | Courage | Shell Energy Stadium | 4155 |
| 101 | | 2021-10-10 | regular_season | KC Current | 0–0 | Thorns | Legends Field | 5438 |
| 102 | | 2021-10-10 | regular_season | Reign | 3–2 | Chicago Stars | Cheney Stadium | 3588 |
| 103 | | 2021-10-13 | regular_season | Courage | 1–2 | Spirit | First Horizon Stadium at WakeMed Soccer Park | 3742 |
| 104 | | 2021-10-14 | regular_season | Thorns | 1–1 | Reign | Providence Park | 11754 |
| 105 | | 2021-10-14 | regular_season | Chicago Stars | 1–0 | Pride | SeatGeek Stadium | 3198 |
| 106 | | 2021-10-14 | regular_season | KC Current | 3–0 | Dash | Legends Field | 3449 |
| 107 | | 2021-10-16 | regular_season | Racing Lou | 3–1 | Pride | Lynn Family Stadium | 8488 |
| 108 | | 2021-10-17 | regular_season | Reign | 0–2 | Spirit | Cheney Stadium | 4009 |
| 109 | | 2021-10-17 | regular_season | Chicago Stars | 2–1 | KC Current | SeatGeek Stadium | 4488 |
| 110 | | 2021-10-17 | regular_season | Courage | 0–3 | Gotham FC | First Horizon Stadium at WakeMed Soccer Park | 7064 |
| 111 | | 2021-10-17 | regular_season | Dash | 0–1 | Thorns | Shell Energy Stadium | 4792 |
| 112 | | 2021-10-23 | regular_season | KC Current | 1–1 | Gotham FC | Legends Field | 4733 |
| 113 | | 2021-10-28 | regular_season | Racing Lou | 1–1 | Gotham FC | Lynn Family Stadium | 6508 |
| 114 | | 2021-10-29 | regular_season | Pride | 0–1 | Chicago Stars | Inter&Co Stadium | |
| 115 | | 2021-10-31 | regular_season | Thorns | 0–0 | Courage | Providence Park | 17584 |
| 116 | | 2021-10-31 | regular_season | KC Current | 0–3 | Reign | Legends Field | 6345 |
| 117 | | 2021-10-31 | regular_season | Gotham FC | 1–1 | Racing Lou | Sports Illustrated Stadium | 6362 |
| 118 | | 2021-10-31 | regular_season | Spirit | 1–0 | Dash | Audi Field | 4542 |